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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG10181-RA through 18771 annotations produced 1 hits

P-glycoprotein65-Dm (Mdr65):

Annotation Number : CG10181
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0004513
Gbrowse : chr3L:6233599-6238836 (-) // 100.0 //
Probeset : 1631925_at
Accessions : protein= NP_476831;, nucleotide= NM_057483;
Pathway : 0005886 // plasma membrane // inferred from direct assay /// 0005887 // integral to plasma membrane // non-traceable aut
Interpro : "0000166 // nucleotide binding // inferred from electronic annotation /// 0005515 // protein binding // inferred from ph
FlyMine data for FBgn0004513.
BDGP gene expression has embryonic in situ data for Mdr65: 18 pix of staining in 5 body parts.
Homophila reports that CG10181 is a close match (2e-11) to human gene ABC1;ABCA1;HDLDT1;TGD (NP_005493), a gene associated with HDL deficiency, type 2, 604091 (3);Tangier disease, 205400 (3);{Coronary artery disease in familial hypercholesterolemia, protection against}, 143890 (3).
BioGrid reports that CG10181 interacts with CG15753 CG33141 CG12020 CG12470 CG14224 CG14369 CG4328 CG8857 .
TRiP has 2 RNAi stocks for FBgn0004513 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain437 124 of 422.10Up
Head187 104 of 4 9.50Up
Eye168 74 of 4 8.52Up
Thoracicoabdominal ganglion479 264 of 424.20Up
Salivary gland3 00 of 4 0.17Down
Crop19 14 of 4 1.00None
Midgut3 10 of 4 0.20Down
Tubule272 1064 of 413.80Up
Hindgut55 64 of 4 2.80Up
Heart4 11 of 4 0.23Down
Fat body5 20 of 4 0.26Down
Ovary4 10 of 4 0.20Down
Testis0 00 of 4 0.00Down
Male accessory glands254 314 of 412.90Up
Virgin spermatheca11 01 of 4 0.58Down
Mated spermatheca10 00 of 4 0.52Down
Adult carcass25 23 of 4 1.30None
Larval CNS735 994 of 437.17Up
Larval Salivary gland4 20 of 4 0.22Down
Larval midgut2 10 of 4 0.13Down
Larval tubule3 10 of 4 0.20Down
Larval hindgut7 12 of 4 0.39Down
Larval fat body3 10 of 4 0.20Down
Larval trachea8 43 of 4 0.41Down
Larval carcass30 14 of 4 1.54Up
S2 cells (growing)0 00 of 4 0.04Down
Whole fly19 24 of 4

Looking for CG10181-RA. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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