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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG1031-RA through 18771 annotations produced 1 hits

fragment A (alpha-Est1):

Annotation Number : CG1031
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0015568
Gbrowse : chr3R:3371448-3374844 (-) // 100.0 //
Probeset : 1623885_at
Accessions : protein= NP_524269;, nucleotide= NM_079545;
Interpro : 0004091 // carboxylesterase activity // inferred from sequence or structural similarity /// 0004091 // carboxylesterase
FlyMine data for FBgn0015568.
BDGP gene expression has embryonic in situ data for alpha-Est1: 13 pix of staining in 6 body parts.
Homophila reports that CG1031 is a close match (4e-18) to human gene AITD3;TG (NP_003226), a gene associated with Goiter, adolescent multinodular (1);Goiter, nonendemic, simple (3);Hypothyroidism, hereditary congenital (3);{Autoimmune thyroid disease, susceptibility to 3}, 608175 (3).
VDRC has 2 RNAi stocks for FBgn0015568 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain9 04 of 4 0.10Down
Head358 244 of 4 2.40Up
Eye140 124 of 4 0.95None
Thoracicoabdominal ganglion13 23 of 4 0.10Down
Salivary gland10 20 of 4 0.07Down
Crop6 01 of 4 0.00Down
Midgut248 84 of 4 1.70Up
Tubule39 24 of 4 0.30Down
Hindgut36 54 of 4 0.20Down
Heart165 64 of 4 1.12None
Fat body411 574 of 4 2.78Up
Ovary120 54 of 4 0.80Down
Testis32 34 of 4 0.20Down
Male accessory glands4 10 of 4 0.00Down
Virgin spermatheca221 184 of 4 1.50Up
Mated spermatheca249 164 of 4 1.69Up
Adult carcass262 144 of 4 1.80Up
Larval CNS6 03 of 4 0.04Down
Larval Salivary gland83 194 of 4 0.57Down
Larval midgut614 254 of 4 4.15Up
Larval tubule241 64 of 4 1.60Up
Larval hindgut62 54 of 4 0.43Down
Larval fat body248 394 of 4 1.70None
Larval trachea73 34 of 4 0.50Down
Larval carcass7 12 of 4 0.05Down
S2 cells (growing)156 124 of 4 1.06None
Whole fly147 44 of 4

Looking for CG1031-RA. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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