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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG11182-RA through 18771 annotations produced 1 hits

Putative homeodomain protein (PHDP):

Annotation Number : CG11182
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0025334
Gbrowse : chr2R:19770707-19771835 (-) // 100.0 //
Probeset : 1639247_at
Accessions : protein= NP_523834;, nucleotide= NM_079110;
Pathway : DNA-dependent // inferred from electronic annotation /// 0045449 // regulation of transcription // inferred from sequen
Interpro : 0005634 // nucleus // inferred from sequence or structural similarity /// 0005634 // nucleus // inferred from electronic
FlyMine data for FBgn0025334.
Homophila reports that CG11182 is a close match (4e-11) to human gene KTCN;PPCD;PPD;RINX;VSX1 (NP_955457), a gene associated with Corneal dystrophy, hereditary polymorphous posterior, 122000 (3);Craniofacial anomalies, empty sella turcica, corneal endothelial changes, and abnormal retinal and auditory bipolar cells (3);Keratoconus, 148300 (3).
BioGrid reports that CG11182 interacts with CG14168 CG1422 CG1676 CG7492 CG8228 CG11248 CG12812 CG13742 CG1467 CG15505 CG17342 CG3035 CG32772 CG33156 CG5111 CG5701 CG7417 CG8831 CG9331 CG1133 .
VDRC has 1 RNAi stocks for FBgn0025334 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain19 14 of 4 5.10Up
Head10 12 of 4 2.60Up
Eye5 00 of 4 1.42None
Thoracicoabdominal ganglion23 14 of 4 6.20Up
Salivary gland5 20 of 4 1.52None
Crop4 00 of 4 1.30None
Midgut8 00 of 4 2.20Up
Tubule3 00 of 4 1.00None
Hindgut5 20 of 4 1.30None
Heart3 10 of 4 0.86None
Fat body9 42 of 4 2.58None
Ovary1 00 of 4 0.30None
Testis5 12 of 4 1.30None
Male accessory glands17 13 of 4 4.60Up
Virgin spermatheca4 10 of 4 1.17None
Mated spermatheca6 00 of 4 1.72None
Adult carcass9 31 of 4 2.50None
Larval CNS24 14 of 4 6.56Up
Larval Salivary gland4 10 of 4 1.26None
Larval midgut5 10 of 4 1.36None
Larval tubule4 00 of 4 1.10None
Larval hindgut3 10 of 4 0.83None
Larval fat body8 11 of 4 2.20None
Larval trachea2 20 of 4 0.74None
Larval carcass8 11 of 4 2.15None
S2 cells (growing)2 00 of 4 0.68None
Whole fly3 10 of 4

Looking for CG11182-RA. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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