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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG4649-RA through 18771 annotations produced 1 hits

Sorbitol dehydrogenase-2 (Sodh-2):

Annotation Number : CG4649
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0022359
Gbrowse : chr3R:6702105-6703988 (+) // 100.0 //
Probeset : 1634742_at
Accessions : protein= NP_524311;, nucleotide= NM_079587;
Interpro : 0003824 // catalytic activity // inferred from electronic annotation /// 0003939 // L-iditol 2-dehydrogenase activity //
FlyMine data for FBgn0022359.
BDGP gene expression has embryonic in situ data for Sodh-2: 19 pix of staining in 4 body parts.
Homophila reports that CG4649 is a close match (7e-11) to human gene ADH1C;ADH3 (NP_000660), a gene associated with {Parkinson disease, susceptibility to}, 168600 (3).
VDRC has 2 RNAi stocks for FBgn0022359 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain111 44 of 4 1.80Up
Head112 134 of 4 1.80Up
Eye52 34 of 4 0.84None
Thoracicoabdominal ganglion182 144 of 4 2.90Up
Salivary gland208 284 of 4 3.35Up
Crop109 134 of 4 1.80Up
Midgut7 20 of 4 0.10Down
Tubule24 53 of 4 0.40Down
Hindgut53 14 of 4 0.90None
Heart100 184 of 4 1.61None
Fat body53 174 of 4 0.86None
Ovary66 34 of 4 1.10None
Testis27 14 of 4 0.40Down
Male accessory glands262 274 of 4 4.20Up
Virgin spermatheca490 234 of 4 7.87Up
Mated spermatheca199 204 of 4 3.20Up
Adult carcass133 94 of 4 2.10Up
Larval CNS40 114 of 4 0.65Down
Larval Salivary gland466 304 of 4 7.49Up
Larval midgut158 284 of 4 2.55Up
Larval tubule62 54 of 4 1.00None
Larval hindgut211 94 of 4 3.40Up
Larval fat body40 34 of 4 0.60Down
Larval trachea561 1684 of 4 9.01Up
Larval carcass882 1504 of 414.16Up
S2 cells (growing)8 20 of 4 0.13Down
Whole fly62 44 of 4

Looking for CG4649-RA. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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