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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG6265-RA through 18771 annotations produced 1 hits

Neprilysin 5 (Nep5):

Annotation Number : CG6265
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0039478
Gbrowse : chr3R:22883616-22889500 (-) // 100.0 //
Probeset : 1625893_a_at
Accessions : protein= NP_001097940; /// NP_651527; /// NP_733186;, nucleotide= NM_001104470; /// NM_143270; /// NM_170307;
Interpro : 0004222 // metalloendopeptidase activity // inferred from sequence or structural similarity /// 0004222 // metalloendope
FlyMine data for FBgn0039478.
BDGP gene expression has embryonic in situ data for CG6265: 4 pix of staining in 1 body parts.
Homophila reports that CG6265 is a close match (7e-17) to human gene ECE1 (NP_001388), a gene associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction (3);{Hypertension, essential, susceptibility to}, 145500 (3).
VDRC has 3 RNAi stocks for FBgn0039478 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain0 00 of 4 0.10Down
Head8 11 of 4 0.70None
Eye3 00 of 4 0.26Down
Thoracicoabdominal ganglion7 02 of 4 0.60Down
Salivary gland289 34 of 423.21Up
Crop7 10 of 4 0.60None
Midgut6 11 of 4 0.50Down
Tubule4 00 of 4 0.30Down
Hindgut4 00 of 4 0.30Down
Heart3 00 of 4 0.31Down
Fat body3 20 of 4 0.26Down
Ovary2 00 of 4 0.20Down
Testis106 54 of 4 8.60Up
Male accessory glands8 21 of 4 0.70None
Virgin spermatheca4 10 of 4 0.39Down
Mated spermatheca3 00 of 4 0.29Down
Adult carcass6 11 of 4 0.60Down
Larval CNS3 01 of 4 0.29Down
Larval Salivary gland8 12 of 4 0.64None
Larval midgut7 10 of 4 0.56Down
Larval tubule4 00 of 4 0.30Down
Larval hindgut3 10 of 4 0.25Down
Larval fat body17 12 of 4 1.40Up
Larval trachea4 11 of 4 0.32Down
Larval carcass5 00 of 4 0.42Down
S2 cells (growing)15 13 of 4 1.24None
Whole fly12 13 of 4

Looking for CG6265-RA. 1 entries matched from 18771, in 1 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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