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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for CG9774-RA through 18771 annotations produced 1 hits

RHO kinase (rok):

Annotation Number : CG9774
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0026181
Gbrowse : chrX:16519141-16531452 (-) // 100.0 //
Probeset : 1626306_at
Accessions : protein= NP_536796;, nucleotide= NM_080535;
Interpro : 0000166 // nucleotide binding // inferred from electronic annotation /// 0004672 // protein kinase activity // inferred
FlyMine data for FBgn0026181.
Homophila reports that CG9774 is a close match (7e-11) to human gene CDS1;CHEK2;CHK2;LFS2;RAD53 (NP_665861), a gene associated with Li-Fraumeni syndrome, 609265 (3);Osteosarcoma, somatic, 259500 (3);Prostate cancer, familial, 176807 (3);{Breast and colorectal cancer, susceptibility to} (3);{Breast cancer, susceptibility to}, 114480 (3).
BioGrid reports that CG9774 interacts with CG18361 CG18361 CG17697 CG8114 CG3595 CG15792 CG2248 CG10701 .
TRiP has 3 RNAi stocks for FBgn0026181 available for purchase.
VDRC has 2 RNAi stocks for FBgn0026181 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain33 34 of 4 0.50Down
Head41 34 of 4 0.60Down
Eye35 24 of 4 0.49Down
Thoracicoabdominal ganglion28 14 of 4 0.40Down
Salivary gland119 94 of 4 1.67Up
Crop144 74 of 4 2.00Up
Midgut91 44 of 4 1.30Up
Tubule26 14 of 4 0.40Down
Hindgut93 64 of 4 1.30None
Heart46 24 of 4 0.64Down
Fat body65 144 of 4 0.92None
Ovary119 34 of 4 1.70Up
Testis24 14 of 4 0.30Down
Male accessory glands74 44 of 4 1.00None
Virgin spermatheca25 24 of 4 0.36Down
Mated spermatheca32 34 of 4 0.46Down
Adult carcass65 64 of 4 0.90None
Larval CNS88 84 of 4 1.23None
Larval Salivary gland102 44 of 4 1.42Up
Larval midgut78 74 of 4 1.09None
Larval tubule76 34 of 4 1.10None
Larval hindgut80 14 of 4 1.12None
Larval fat body35 34 of 4 0.50Down
Larval trachea88 64 of 4 1.23None
Larval carcass74 84 of 4 1.04None
S2 cells (growing)120 34 of 4 1.68Up
Whole fly71 64 of 4

Looking for CG9774-RA. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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