FlyAtlas: the Drosophila gene expression atlas

Biotechnology & Biological Sciences Research Council

Home & Search

Batch/table Search

Tissues Search

BLASTP Search

About & FAQ

Top 50

Original data

Interesting meta-analysis

Links

Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

Searching for FBGN0003732 through 18771 annotations produced 1 hits

topoisomerase II (Top2):

Annotation Number : CG10223
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0003732
Gbrowse : chr2L:19447361-19453507 (-) // 100.0 //
Probeset : 1631837_at
Accessions : protein= NP_476760;, nucleotide= NM_057412;
Pathway : DNA-dependent // inferred from electronic annotation /// 0007052 // mitotic spindle organization // inferred from mutan
Interpro : 0005625 // soluble fraction // inferred from direct assay /// 0005626 // insoluble fraction // inferred from direct assa
FlyMine data for FBgn0003732.
Homophila reports that CG10223 is a close match (0) to human gene TOP2;TOP2A (NP_001058), a gene associated with DNA topoisomerase II, resistance to inhibition of, by amsacrine (3).
TRiP has 2 RNAi stocks for FBgn0003732 available for purchase.
VDRC has 1 RNAi stocks for FBgn0003732 available for purchase.

Tissue	mRNA Signal	Present Call	Enrichment	Affy Call
Brain	219 ± 6	4 of 4	0.60	Down
Head	125 ± 8	4 of 4	0.30	Down
Eye	151 ± 11	4 of 4	0.38	Down
Thoracicoabdominal ganglion	219 ± 10	4 of 4	0.60	Down
Salivary gland	144 ± 5	4 of 4	0.37	Down
Crop	137 ± 6	4 of 4	0.30	Down
Midgut	105 ± 2	4 of 4	0.30	Down
Tubule	166 ± 12	4 of 4	0.40	Down
Hindgut	126 ± 2	4 of 4	0.30	Down
Heart	97 ± 5	4 of 4	0.25	Down
Fat body	77 ± 19	4 of 4	0.20	Down
Ovary	1042 ± 17	4 of 4	2.60	Up
Testis	196 ± 2	4 of 4	0.50	Down
Male accessory glands	373 ± 19	4 of 4	0.90	None
Virgin spermatheca	189 ± 18	4 of 4	0.48	Down
Mated spermatheca	217 ± 13	4 of 4	0.55	Down
Adult carcass	99 ± 16	4 of 4	0.30	Down
Larval CNS	1372 ± 66	4 of 4	3.49	Up
Larval Salivary gland	517 ± 46	4 of 4	1.32	None
Larval midgut	155 ± 5	4 of 4	0.40	Down
Larval tubule	306 ± 6	4 of 4	0.80	None
Larval hindgut	226 ± 3	4 of 4	0.58	Down
Larval fat body	112 ± 4	4 of 4	0.30	Down
Larval trachea	593 ± 59	4 of 4	1.51	Up
Larval carcass	296 ± 16	4 of 4	0.75	Down
S2 cells (growing)	739 ± 19	4 of 4	1.88	Up
Whole fly	393 ± 28	4 of 4

Looking for FBgn0003732. 1 entries matched from 18771, in 1 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720