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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for FBGN0004619 through 18771 annotations produced 1 hits

glutamate receptor (Glu-RI):

Annotation Number : CG8442
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0004619
Gbrowse : chr3L:6617133-6628166 (+) // 100.0 //
Probeset : 1633583_at
Accessions : protein= NP_476855;, nucleotide= NM_057507;
Pathway : 0005886 // plasma membrane // inferred from sequence or structural similarity /// 0005886 // plasma membrane // inferred
Interpro : 0004872 // receptor activity // inferred from electronic annotation /// 0004970 // ionotropic glutamate receptor activit
FlyMine data for FBgn0004619.
BDGP gene expression has embryonic in situ data for Glu-RI: 20 pix of staining in 8 body parts.
Homophila reports that CG8442 is a close match (6e-144) to human gene GLUR6;GRIK2;MRT6 (NP_786944), a gene associated with Mental retardation, autosomal recessive, 6, 611092 (3).
TRiP has 3 RNAi stocks for FBgn0004619 available for purchase.
VDRC has 3 RNAi stocks for FBgn0004619 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain255 174 of 489.50Up
Head43 24 of 415.10Up
Eye8 11 of 4 2.93None
Thoracicoabdominal ganglion196 54 of 468.90Up
Salivary gland4 00 of 4 1.71None
Crop1 00 of 4 0.60None
Midgut1 00 of 4 0.50None
Tubule1 00 of 4 0.50Down
Hindgut3 10 of 4 1.40None
Heart2 10 of 4 0.89None
Fat body1 10 of 4 0.56None
Ovary1 00 of 4 0.70None
Testis8 11 of 4 2.80Up
Male accessory glands1 00 of 4 0.40None
Virgin spermatheca1 00 of 4 0.54None
Mated spermatheca1 00 of 4 0.49None
Adult carcass5 20 of 4 2.00None
Larval CNS67 124 of 423.54Up
Larval Salivary gland3 10 of 4 1.05None
Larval midgut0 00 of 4 0.31None
Larval tubule1 00 of 4 0.60None
Larval hindgut2 00 of 4 0.69None
Larval fat body5 20 of 4 1.90None
Larval trachea1 00 of 4 0.36None
Larval carcass7 10 of 4 2.62Up
S2 cells (growing)1 00 of 4 0.60None
Whole fly2 10 of 4

Looking for FBgn0004619. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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