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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for FBGN0015569 through 18771 annotations produced 1 hits

Esterase-10 (alpha-Est10):

Annotation Number : CG1131
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0015569
Gbrowse : chr3R:3312551-3314296 (-) // 99.26 //
Probeset : 1626350_at
Accessions : protein= NP_524257;, nucleotide= NM_079533;
Interpro : 0004091 // carboxylesterase activity // inferred from sequence or structural similarity /// 0004091 // carboxylesterase
FlyMine data for FBgn0015569.
Homophila reports that CG1131 is a close match (8e-16) to human gene AITD3;TG (NP_003226), a gene associated with Goiter, adolescent multinodular (1);Goiter, nonendemic, simple (3);Hypothyroidism, hereditary congenital (3);{Autoimmune thyroid disease, susceptibility to 3}, 608175 (3).
VDRC has 2 RNAi stocks for FBgn0015569 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain6 02 of 4 0.10Down
Head151 104 of 4 2.20Up
Eye71 74 of 4 1.03None
Thoracicoabdominal ganglion3 11 of 4 0.00Down
Salivary gland20 41 of 4 0.29Down
Crop463 134 of 4 6.70Up
Midgut61 34 of 4 0.90None
Tubule13 13 of 4 0.20Down
Hindgut212 104 of 4 3.10Up
Heart114 184 of 4 1.65None
Fat body178 204 of 4 2.57Up
Ovary112 34 of 4 1.60Up
Testis117 44 of 4 1.70Up
Male accessory glands18 24 of 4 0.30Down
Virgin spermatheca22 14 of 4 0.33Down
Mated spermatheca45 54 of 4 0.65Down
Adult carcass169 234 of 4 2.40Up
Larval CNS5 14 of 4 0.08Down
Larval Salivary gland10 23 of 4 0.16Down
Larval midgut188 174 of 4 2.71Up
Larval tubule23 14 of 4 0.30Down
Larval hindgut51 14 of 4 0.74None
Larval fat body29 84 of 4 0.40Down
Larval trachea53 94 of 4 0.77None
Larval carcass108 164 of 4 1.57None
S2 cells (growing)86 24 of 4 1.24None
Whole fly69 64 of 4

Looking for FBgn0015569. 1 entries matched from 18771, in 1 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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