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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for FBGN0019686 through 18771 annotations produced 1 hits

maternal nuclear kinase (lok):

Annotation Number : CG10895
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0019686
Gbrowse : chr2L:20061476-20064381 (+) // 100.0 //
Probeset : 1625038_s_at
Accessions : protein= NP_477218; /// NP_477219; /// NP_724241;, nucleotide= NM_057870; /// NM_057871; /// NM_165318;
Pathway : signal transduction resulting in induction of apoptosis // inferred from mutant phenotype"
Interpro : 0005634 // nucleus // inferred from direct assay /// 0005634 // nucleus // inferred from electronic annotation /// 00057
FlyMine data for FBgn0019686.
BDGP gene expression has embryonic in situ data for lok: 60 pix of staining in 26 body parts.
Homophila reports that CG10895 is a close match (7e-12) to human gene JAK2 (NP_004963), a gene associated with Leukemia, acute myelogenous, 601626 (3);Myelofibrosis, idiopathic, 254450 (3);Myeloproliferative disorder with erythrocytosis (3);Polycythemia vera, 263300 (3);Thrombocythemia, essential, 187950 (3);{Budd-Chiari syndrome}, 600880 (3).
BioGrid reports that CG10895 interacts with CG3736 CG12306 CG3325 CG31069 CG1395 CG33336 CG33336 CG3018 CG5650 CG8667 CG4602 CG33553 CG9776 .
TRiP has 1 RNAi stocks for FBgn0019686 available for purchase.
VDRC has 3 RNAi stocks for FBgn0019686 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain13 02 of 4 0.00Down
Head33 24 of 4 0.00Down
Eye22 24 of 4 0.03Down
Thoracicoabdominal ganglion12 22 of 4 0.00Down
Salivary gland40 64 of 4 0.06Down
Crop76 14 of 4 0.10Down
Midgut47 34 of 4 0.10Down
Tubule66 94 of 4 0.10Down
Hindgut52 34 of 4 0.10Down
Heart20 14 of 4 0.03Down
Fat body32 84 of 4 0.05Down
Ovary1511 184 of 4 2.10Up
Testis44 24 of 4 0.10Down
Male accessory glands52 24 of 4 0.10Down
Virgin spermatheca33 24 of 4 0.05Down
Mated spermatheca24 04 of 4 0.03Down
Adult carcass59 154 of 4 0.10Down
Larval CNS128 74 of 4 0.18Down
Larval Salivary gland35 34 of 4 0.05Down
Larval midgut40 34 of 4 0.06Down
Larval tubule48 24 of 4 0.10Down
Larval hindgut53 54 of 4 0.08Down
Larval fat body29 34 of 4 0.00Down
Larval trachea97 124 of 4 0.14Down
Larval carcass46 14 of 4 0.07Down
S2 cells (growing)162 94 of 4 0.23Down
Whole fly710 114 of 4

Looking for FBgn0019686. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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