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FlyAtlas: the Drosophila gene expression atlas

University of Glasgow
Biotechnology & Biological Sciences Research Council
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Latest news: FlyAtlas2 : A Database web-app for fruitfly expression with added RNA & miRNA goodness ! Click here to visit the application. Read all about it here.

This dataset was generated by Venkat Chintapalli, Jing Wang & Julian Dow at the University of Glasgow with funding from the UK's BBSRC.
It gives you a quick answer to the question: where is my gene of interest expressed/enriched in the adult fly?
For each gene & tissue, you're given the mRNA SIGNAL (how abundant the mRNA is), the mRNA ENRICHMENT (compared to whole flies), and the Affymetrix PRESENT CALL (out of 4 arrays, how many times it was detectably expressed).

String to look for? (e.g. vha, cell adhesion, receptor, aquaporin, adenylate, CG1147, pnt)

Searching for FBGN0035076 through 18771 annotations produced 1 hits

Ance-5 (Ance-5):

Annotation Number : CG10142
FlyAtlas2 : Click Here for expression data based on RNA-Seq and or miRNA-Seq analyses
Flybase ID : FBgn0035076
Gbrowse : chr2R:20776148-20778545 (-) // 100.0 //
Probeset : 1636623_at
Accessions : protein= NP_573392;, nucleotide= NM_133164;
Pathway : 0016020 // membrane // inferred from electronic annotation
Interpro : 0004180 // carboxypeptidase activity // inferred from electronic annotation /// 0008233 // peptidase activity // inferre
FlyMine data for FBgn0035076.
Homophila reports that CG10142 is a close match (6e-65) to human gene ACE;ACE1;DCP1 (NP_000780), a gene associated with Renal tubular dysgenesis, 267430 (3);[Angiotensin I-converting enzyme, benign serum increase] (3);{Alzheimer disease, susceptibility to}, 104300 (3);{Diabetic nephropathy, susceptibility to}, 603933 (3);{Myocardial infarction, susceptibility to} (3);{SARS, progression of} (3).
VDRC has 2 RNAi stocks for FBgn0035076 available for purchase.

TissuemRNA SignalPresent CallEnrichmentAffy Call
Brain48 04 of 4 0.70None
Head325 364 of 4 4.90Up
Eye198 94 of 4 3.01Up
Thoracicoabdominal ganglion43 54 of 4 0.70Down
Salivary gland15 41 of 4 0.24Down
Crop13 21 of 4 0.20Down
Midgut4 10 of 4 0.10Down
Tubule11 11 of 4 0.20Down
Hindgut19 43 of 4 0.30Down
Heart719 254 of 410.89Up
Fat body424 944 of 4 6.42Up
Ovary1 00 of 4 0.00Down
Testis14 14 of 4 0.20Down
Male accessory glands2 10 of 4 0.00Down
Virgin spermatheca211 224 of 4 3.20Up
Mated spermatheca211 74 of 4 3.20Up
Adult carcass341 224 of 4 5.20Up
Larval CNS4 10 of 4 0.06Down
Larval Salivary gland5 10 of 4 0.08Down
Larval midgut7 11 of 4 0.11Down
Larval tubule6 11 of 4 0.10Down
Larval hindgut19 24 of 4 0.29Down
Larval fat body29 22 of 4 0.50Down
Larval trachea62 74 of 4 0.95None
Larval carcass119 44 of 4 1.82Up
S2 cells (growing)8 13 of 4 0.13Down
Whole fly66 64 of 4

Looking for FBgn0035076. 1 entries matched from 18771, in 2 s.

Chintapalli, V. R., Wang, J. and Dow, J. A. T. (2007). Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39: 715-720

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